Prevalence of the fsr locus in Enterococcus faecalis infections.
نویسندگان
چکیده
The fsr locus of Enterococcus faecalis confers virulence in animal models. A retrospective analysis of fsr prevalence in diverse E. faecalis clinical isolates demonstrated fsr in all endocarditis isolates versus 53% of stool isolates (P = 0.005). This supports a role for fsr-mediated virulence in the pathogenesis of enterococcal infections in humans.
منابع مشابه
Molecular epidemiology of the fsr locus and of gelatinase production among different subsets of Enterococcus faecalis isolates.
We examined 215 Enterococcus faecalis isolates and found that neither the two-component regulatory locus fsr (E. faecalis regulator) nor gelatinase production was more common in disease-associated isolates than in isolates colonizing healthy individuals (ca. 60 to 65%). The majority of gelatinase-negative isolates, including 14 endocarditis isolates (of 80 isolates tested), contained the previo...
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The expression of two Enterococcus faecalis extracellular virulence-related proteins, gelatinase (GelE) and serine protease (SprE), has been shown to be positively regulated by the fsr quorum-sensing system. We recently developed a novel system for studying E. faecalis pathogenicity that involves killing of the nematode worm Caenorhabditis elegans and showed that an E. faecalis fsrB mutant (str...
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Enterococcus faecalis is an important nosocomial pathogen causing serious invasive infections. One of the virulence factors of this pathogen, gelatinase GelE, is a protease whose gene expression is regulated by the Fsr quorum sensing system. In this study, we used a well-characterized collection of 153 clinical E. faecalis isolates to investigate the distribution of genes involved in gelatinase...
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Pillai and colleagues (3) in 2002 reported a striking correlation (100.0% positive; P 0.005) of the fsr virulence gene with Enterococcus faecalis isolated from a collection of endocarditis cases. The comparison group of stool culture isolates had a significantly lower rate of positive fsr tests (53%) by methods described earlier by Qin et al. (4, 5). The fsr locus has been noted to be widely di...
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عنوان ژورنال:
- Journal of clinical microbiology
دوره 40 7 شماره
صفحات -
تاریخ انتشار 2002